It is common for people taking peginterferon to get skin irritation around the injection site.
Dry skin and rashes are also common side effects of combination therapy. If you have developed a rash or dry, itchy skin, show your healthcare provider. He or she may want to prescribe a cream or tell you about some lotions that will help clear your skin.
Also, avoid taking hot showers or baths. These can make rashes or dry skin worse.