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HCV Combination Therapy: Who Should Not Use It?

Possible Peginterferon Interactions and Ribavirin Interactions

It is believed that, for the most part, peginterferon and ribavirin do not result in bad interactions with food or other drugs. However, it is still important for your healthcare provider to know what other medications you are currently taking, or if you stop or start taking any other medicines while on combination therapy.
If you are taking any medications -- either prescription or over-the-counter drugs -- be sure to tell your healthcare provider about them before you begin combination therapy. You may need to take a different amount of medicine or have more frequent blood tests during your treatment.
Let your healthcare provider know if you have been using any vitamin supplements or herbal remedies. A few of these may change how long the combination therapy stays in your body. Also, let your provider know if you have had allergic reactions to any type of medication in the past. This will help him or her know what kinds of medication you need to avoid.
By knowing the medications and other supplements you are already taking, your healthcare provider can help you design the treatment plan that is best for you.

Possible Hepatitis C Protease Inhibitor Interactions

In contrast to peginterferon and ribavirin, the hepatitis C protease inhibitors (Victrelis®, Incivek®, Olysio™) are very likely to interact with other medications. In fact, if you must take certain medications, you might not be able to take Victrelis or Incivek. Some of the drug interactions can be life-threatening.
(For more information, please see Incivek Drug Interactions and Victrelis Drug Interactions.)

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