Some people find it hard to take their medicines if they have a change in their normal routine. These changes include things like: losing a job or getting a new job, having to work new hours, moving, going on vacation, and weekends. Things change in our lives all the time, but if you're ready for a change, it will be easier to stay on schedule with your medications. No matter what the change, have a plan ready to make sure that you are still taking your medications.