INCIVEK Drug Interactions
Certain Anti-Seizure Medications
Taking INCIVEK with certain anti-seizure medications can affect the blood levels of INCIVEK and of the seizure medicines. INCIVEK may increase blood levels of carbamazepine, and could increase or decrease blood levels of phenytoin and phenobarbital. In addition, any of those seizure medications may decrease INCIVEK blood levels, potentially making it less effective. Talk to your healthcare provider before taking these medications together.
INCIVEK can increase blood levels of certain benzodiazepines, potentially increasing your risk for side effects. It can also decrease blood levels of zolpidem.
Talk to your healthcare provider before taking INCIVEK with one of these medicines. He or she may need to adjust the dose of your benzodiazepine or sedative. Oral midazolam or oral triazolam and INCIVEK should not be taken together. Injectable midazolam should only be given with INCIVEK in a healthcare setting, where appropriate monitoring is possible.
INCIVEK can increase blood levels of cyclosporine, tacrolimus, and sirolimus, possibly increasing the risk for side effects. If you take these medications together, your healthcare provider will need to monitor you more closely for potential side effects. He or she will check your blood levels of your immunosuppressant, and decrease your dose as necessary.
INCIVEK increases the risk of dangerous muscle problems with certain statins. It should never be combined with lovastatin or simvastatin, and combining it with atorvastatin is not recommended. INCIVEK may be combined with fluvastatin, pitavastatin, pravastatin, or rosuvastatin, although extra caution and monitoring are required.
INCIVEK and cisapride should never be combined, due to the increased risk of a dangerous irregular heart rhythm (arrhythmia).
Combining INCIVEK with colchicine could increase the levels of colchicine in your body, increasing your risk for potentially serious side effects. People with kidney and liver disease (other than hepatitis C) should not take these medicines together. If they are taken together, a lower colchicine dose should be used.