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INCIVEK Drug Interactions

Corticosteroids
Combining INCIVEK with corticosteroids could result in increased levels of corticosteroids in the bloodstream, which could increase your risk for potentially serious side effects. INCIVEK should not be used with oral, inhaled, or nasal corticosteroid medicines unless absolutely necessary.
 
CYP 3A4 Inducer Medications
The liver breaks down INCIVEK using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inducers can increase the activity of these enzymes. Combining INCIVEK with one of these CYP 3A4 inducers may decrease the level of INCIVEK in your bloodstream, possibly making it less effective. Talk to your healthcare provider before taking INCIVEK with a CYP 3A4 inducer.
 
INCIVEK should never be combined with rifampin or St. John's wort.
 
CYP 3A4 Inhibitor Medications
The liver breaks down INCIVEK using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Combining INCIVEK with one of these CYP 3A4 inhibitors may increase the level of INCIVEK in your bloodstream, increasing your risk for side effects. Talk to your healthcare provider before taking INCIVEK with a CYP 3A4 inhibitor.
 
Digoxin
INCIVEK may increase levels of digoxin in the bloodstream. Your healthcare provider may decide to monitor your digoxin levels using a simple blood test, especially when you first start or stop taking INCIVEK.
 
Desipramine
Taking INCIVEK with desipramine could increase the level of desipramine in your bloodstream, potentially increasing your risk for side effects, such as nausea, dizziness, and low blood pressure. Your healthcare provider may need to give you a lower desipramine dose during INCIVEK treatment.
 
Ergot Medications
INCIVEK increases the risk of dangerous ergot side effects. Such medications should never be combined.
  
Escitalopram
INCIVEK can decrease blood levels of escitalopram, potentially making it less effective. Although this is not considered a serious interaction, your healthcare provider may choose to monitor you more closely during INCIVEK treatment and increase your escitalopram dose if needed.
 
Fentanyl or Alfentanil
INCIVEK may increase blood levels of fentanyl or alfentanil. Check with your healthcare provider before taking such medications together. Extra monitoring may be required to avoid dangerous side effects.

INCIVEK Drug Information

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