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INCIVEK Drug Interactions

Hormonal Birth Control
INCIVEK has been shown to decrease blood levels of ethinyl estradiol, which could make birth control pills that contain estrogen less effective. Women taking INCIVEK should use two forms of birth control, other than hormonal birth control.
 
Methadone
Taking INCIVEK with methadone could decrease levels of methadone in your bloodstream, potentially making it less effective. Your healthcare provider may choose to monitor your response to methadone, and adjust your dose if needed.
 
Non-Nucleoside Reverse Transcriptase Inhibitors
Combining INCIVEK with efavirenz may result in lower blood levels of both efavirenz and INCIVEK, possibly decreasing the effectiveness of the medications. Combining INCIVEK with tenofovir may cause increased levels of tenofovir in the bloodstream, which could increase the risk for tenofovir side effects. Your healthcare provider will need to monitor you more closely if you take these medications together.
 
P-Glycoprotein (Pgp) Inhibitors
P-glycoprotein is a protein found in the body. One of its roles is to help remove substances, such as medications, out of the tissues so they can be excreted through the urine or feces. Pgp helps remove INCIVEK from the body. Certain other medications (known as Pgp inhibitors) decrease the activity of Pgp.
 
Taking INCIVEK with one of these Pgp inhibitors causes INCIVEK to be removed more slowly, potentially increasing the amount of INCIVEK in your bloodstream and increasing your risk for serious side effects. Your healthcare provider may choose to monitor you more closely for side effects if you take INCIVEK with a Pgp inhibitor.
 
The prescribing information for INCIVEK specifically states that combining the drug with atorvastatin should be avoided.

INCIVEK Drug Information

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