Hepatitis C Home > Sovaldi Dosage

Sovaldi comes as tablets that are taken to treat hepatitis C infections. Although the dosage of Sovaldi is the same for everyone (400 mg once daily), the amount of time you take it will vary, depending on the type of hepatitis C virus you have. Sovaldi is usually combined with one or two other medications, and can be used for 12 to 48 weeks.


An Introduction to Dosing With Sovaldi

There is only one standard recommended dose of Sovaldi™ (sofosbuvir). However, the length of treatment will depend on a variety of factors, including:
As is always the case, do not adjust your dose unless your healthcare provider specifically tells you to do so.

What Is the Recommended Sovaldi Dosage?

The recommended dosage for all types of hepatitis C is Sovaldi 400 mg once daily, taken by mouth, with or without food. How long you take it will vary, as follows:
  • Genotype 1 or 4 -- Sovaldi plus peginterferon alfa plus ribavirin for 12 weeks
  • Genotype 2 -- Sovaldi plus ribavirin for 12 weeks
  • Genotype 3 -- Sovaldi plus ribavirin for 24 weeks.
For people with genotype 1 who cannot take peginterferon, a regimen of Sovaldi plus ribavirin for 24 weeks is acceptable. Sovaldi is also approved to be used for up to 48 weeks in people with hepatitis C awaiting liver transplant, to help reduce the risk of reinfecting the new liver.

General Information on Taking Sovaldi

Some considerations to keep in mind during treatment with Sovaldi include the following:
  • Sovaldi comes in tablet form. It is usually taken by mouth once a day, with or without food, for 12 to 48 weeks.
  • Make sure to take this medication at the same time each day to keep an even level of it in your bloodstream.
  • For the medication to work properly, it must be taken as prescribed. Do not stop taking Sovaldi unless your healthcare provider tells you to do so. Missing doses can increase the chance of the virus becoming resistant to the medication, which can make the medication less effective.
  • If you are unsure about anything related to your dosage, please talk with your healthcare provider, nurse, or pharmacist.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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