Hepatitis C Home > Sovaldi

Those who have chronic hepatitis C may receive a medication called Sovaldi. This prescription drug is approved for use in combination with other hepatitis medications. It comes as a tablet that is taken once daily for 12 to 48 weeks. Side effects include headaches, nausea, and insomnia.


What Is Sovaldi?

Sovaldi™ (sofosbuvir) is a prescription medication approved for the treatment of chronic hepatitis C in combination with one or two other medications -- ribavirin (Copegus®, Rebetol®, RibaPak®, Ribasphere®) and sometimes peginterferon alfa (Pegasys®, PEG-Intron®). The exact regimen will depend on the type of hepatitis C infection.
(Click Sovaldi Uses for more information, including possible off-label uses.)

Who Makes This Medication?

Sovaldi is made by Gilead Sciences, Inc.

How Does Sovaldi Work?

Sovaldi is classified as a hepatitis C virus (HCV) nucleotide analog NS5B polymerase inhibitor. It works by interfering with the activity of NS5B polymerase, an enzyme crucial to the replication of the virus. By inhibiting NS5B polymerase, Sovaldi helps stop the virus from reproducing itself.

When and How to Take It

Some general considerations to keep in mind during treatment with Sovaldi include the following:
  • Sovaldi comes in tablet form. It is usually taken by mouth once a day, with or without food, for 12 to 48 weeks.
  • Make sure to take this medication at the same time each day to keep an even level of it in your bloodstream.
  • For the medication to work properly, it must be taken as prescribed. Do not stop taking Sovaldi unless your healthcare provider tells you to do so. Missing doses can increase the chance of the virus becoming resistant to the medication, which can make the medication less effective.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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