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Pegasys Uses

If you have hepatitis B or C, you may benefit from Pegasys. This prescription medicine is specifically designed to treat chronic hepatitis C in adults and children as young as five years old. It is only approved to treat hepatitis B in adults age 18 and older. A healthcare provider also may prescribe Pegasys for unapproved uses, such as for treating cancer.

What Is Pegasys Used For?

Pegasys® (peginterferon alfa-2a) is a prescription medication approved for chronic hepatitis C or chronic hepatitis B. For hepatitis C, Pegasys works best when combined with ribavirin, although it can also be used alone if necessary. For hepatitis C virus genotype 1 infections, it works even better when combined with both ribavirin and a hepatitis C protease inhibitor like Incivek® or Victrelis®, although such a combination is not appropriate for all individuals.

Using Pegasys for Hepatitis B and C

Hepatitis B and C are diseases that involve inflammation of the liver due to an infection with the hepatitis C virus (HCV) or hepatitis B virus (HBV). People get hepatitis B or C by coming in contact with an infected person's blood or bodily fluids (see Hepatitis C Transmission and Hepatitis B Transmission for more information).
Once someone is infected with hepatitis B or C, the infection can be acute, or become chronic. In an acute infection, the virus is cleared from the body within a few months. With hepatitis B, most people will completely clear the virus within a few months, although a few will end up with chronic hepatitis B. With hepatitis C, however, most of the time, the virus is not completely cleared, and the infection becomes chronic, or continues for a long time. Chronic hepatitis B or C can cause liver problems, including:
  • Liver cirrhosis (scarring)
  • Cancer
  • Liver failure.
The goal of treatment for chronic hepatitis B or C is to completely clear the body of the virus. Clearing the virus can ultimately help reduce liver swelling, stop the scarring, and possibly reverse some of the liver damage. It may also reduce the long-term risk of liver cancer.
When treating hepatitis C, Pegasys works best when combined with ribavirin and a hepatitis C protease inhibitor drug like Incivek or Victrelis. This is the preferred regimen for adults with hepatitis C genotype 1. For other hepatitis C genotypes and for people 5 to 17 years of age, regardless of genotype, the preferred regimen is peginterferon alfa-2a plus ribavirin.
For Pegasys to be used alone for hepatitis C, there must be a good reason why someone cannot or should not take ribavirin.
When treating hepatitis B, Pegasys is typically used alone and is approved only for adults.

Pegasys Drug Information

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