PegIntron Drug Interactions
Combining PegIntron with certain drugs, such as zidovudine, methadone, or fluoxetine, may lead to negative interactions. Some of these reactions may increase the risk for side effects, decrease the effectiveness of your medication, or cause other complications. Before starting treatment with PegIntron, make sure your healthcare provider knows about all medications, vitamins, and supplements you are taking.
An Overview of Interactions With PegIntronPegIntron® (peginterferon alfa-2b) may react with several other medications. Some of the drugs that may interact with PegIntron include but are not limited to:
- Aldesleukin (Proleukin®)
- Fluoxetine (Prozac®, Sarafem®, Symbyax®)
- Methadone (Dolophine®, Methadose®)
- Pegloticase (Krystexxa™)
- Telbivudine (Tyzeka®)
- Theophylline products (Elixophyllin®, Theo-24®, TheoCap™, Theochron®, Uniphyl®)
- Zidovudine (Retrovir®) or combination medications that contain zidovudine (Combivir®, Trizivir®).
PegIntron Drug Interactions ExplainedThe following sections explain in detail the potentially negative reactions that can occur when PegIntron is combined with any of the drugs listed above.
Interferons like PegIntron may increase the risk of aldesleukin side effects. In general, aldesleukin should not be combined with interferon medications.
PegIntron may decrease the level of fluoxetine in the blood, making it less effective. Check with your healthcare provider before using these medications together.