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Sovaldi Drug Interactions

If you are about to begin treatment with Sovaldi, your healthcare provider will need to know about all medications, supplements, and vitamins you are taking. Many products can cause drug interactions with Sovaldi, potentially decreasing its effectiveness. Certain antibiotics, seizure medications, and even supplements like St. John's wort can cause problems.

 

An Overview of Interactions With Sovaldi

Sovaldi™ (sofosbuvir) can potentially interact with a number of other medications. Some of the medicines that may lead to drug interactions with Sovaldi include but are not limited to:
 
  • Certain antibiotics, such as:
    • Rifabutin (Mycobutin®)
    • Rifampin (Rifadin®, Rifamate®, Rifater®, Rimactane®)
    • Rifapentine (Priftin®)
     

Sovaldi Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when any of the drugs mentioned above are combined with Sovaldi.
 
Certain Antibiotics
Some antibiotics can decrease the level of Sovaldi in the blood, making it less effective. In general, such combinations should be avoided. Rifampin, in particular, should never be combined with Sovaldi.
 
Certain Seizure Medications
Some seizure medications can decrease the level of Sovaldi in the blood, making it less effective. In general, such combinations should be avoided.  
 
St. John's Wort
St. John's wort can significantly lower the level of Sovaldi in the blood, making it significantly less effective. Never take these medications together.
 
Tipranavir/Ritonavir
The combination of tipranavir and ritonavir can decrease the level of Sovaldi in the blood, making it less effective. In general, these medications should not be used together.
 

Sovaldi Medication Information

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